What are gallstones?
Gallstones are small, pebble-like substances that develop in the gallbladder. The gallbladder is a small, pear-shaped sac located below the liver in the right upper abdomen. Gallstones form when liquid stored in the gallbladder hardens into pieces of stone-like material. The liquid, called bile, helps the body digest fats. Bile is made in the liver, then stored in the gallbladder until the body needs it. The gallbladder contracts and pushes the bile into a tube called the common bile duct (CBD) that carries it to the small intestine, where it helps with digestion.
Bile contains water, cholesterol, fats, bile salts, proteins, and bilirubin, a waste product. Bile salts break up fat, and bilirubin gives bile and stool a yellowish-brown color. If the liquid bile contains too much cholesterol, bile salts, or bilirubin, it can harden into gallstones. The two types of gallstones are cholesterol stones and pigment stones. Cholesterol stones are usually yellow-green and are made primarily of hardened cholesterol. They account for about 80 percent of gallstones. Pigment stones are small, dark stones made of bilirubin. Gallstones can be as small as a grain of sand or as large as a golf ball. The gallbladder can develop just one large stone, hundreds of tiny stones, or a combination of the two.
Gallstones can block the normal flow of bile if they move from the gallbladder and lodge in any of the ducts that carry bile from the liver to the small intestine. The ducts include:
- Hepatic ducts: carry bile out of the liver
- Cystic duct: takes bile to and from the gallbladder
- Common bile duct (CBD): takes bile from the cystic and hepatic ducts to the small intestine
Bile trapped in these ducts can cause inflammation in the gallbladder, the ducts, or in rare cases, the liver. Other ducts open into the common bile duct, including the pancreatic duct, which carries digestive enzymes out of the pancreas. Sometimes gallstones passing through the common bile duct provoke inflammation in the pancreas called gallstone pancreatitis, an extremely painful and potentially dangerous condition.
If any of the bile ducts remain blocked for a significant period of time, severe damage or infection can occur in the gallbladder, liver, or pancreas. Left untreated, the condition can be fatal. Warning signs of a serious problem are fever, jaundice, and persistent pain.
What causes gallstones?
Cholesterol stones form when bile contains too much cholesterol, too much bilirubin, or not enough bile salts. They can also form when the gallbladder does not empty completely or often enough. The reason these imbalances occur is not known. The cause of pigment stones is not fully understood. The stones tend to develop in people who have liver Cirrhosis, biliary tract infections, or hereditary blood disorders, such as sickle cell anemia, in which the liver makes too much bilirubin.
The mere presence of gallstones may cause more gallstones to develop. Other factors that contribute to the formation of gallstones, particularly cholesterol stones, include:
- Sex: Women are twice as likely as men to develop gallstones. Excess estrogen from pregnancy, hormone replacement therapy, and birth control pills appear to increase cholesterol levels in bile and decrease gallbladder movement, which can lead to gallstones.
- Family history: Gallstones often run in families, pointing to a possible genetic link.
- Weight: Even moderately overweight increases the risk for developing gallstones. The most likely reason is that the amount of bile salts in bile is reduced, resulting in more cholesterol. Increased cholesterol reduces gallbladder emptying. Obesity is a major risk factor for gallstones, especially in women.
- Diet: High fat and cholesterol intake increase the risk of gallstones due to increased cholesterol in the bile and reduced gallbladder emptying. A low fiber diet also increases the risk.
- Rapid weight loss: As the body metabolizes fat during prolonged fasting and rapid weight loss, such as “crash diets,” the liver secretes extra cholesterol into bile, which can cause gallstones. In addition, the gallbladder does not empty properly.
- Age: People older than age 60 are more likely to develop gallstones than younger people. As people age, the body tends to secrete more cholesterol into bile.
- Ethnicity: American Indians have a genetic predisposition to secrete high levels of cholesterol in bile. In fact, they have the highest rate of gallstones in the United States. The majority of American Indian men have gallstones by age 60. Among the Pima Indians of Arizona, 70 percent of women have gallstones by age 30. Mexican American men and women of all ages also have high rates of gallstones.
- Cholesterol-lowering drugs: Drugs that lower cholesterol levels in the blood actually increase the amount of cholesterol secreted into bile. In turn, the risk of gallstones increases.
- Diabetes: People with diabetes generally have high levels of fatty acids called triglycerides. These fatty acids may increase the risk of gallstones.
Who is at risk for gallstones?
- Women
- Pregnancy
- Hormone replacement therapy
- Birth control pills
- Age over 60
- American Indians
- Mexican Americans
- Overweight individuals
- Rapid weight loss
- Family history of gallstones
- diabetes
- Cholesterol-lowering drugs
What are the symptoms of gallstones?
As gallstones move into the bile ducts and create blockage, pressure increases in the gallbladder and one or more symptoms may occur. Symptoms of blocked bile ducts are often called a gallbladder “attack” because they occur suddenly. Gallbladder attacks often follow fatty meals, and they may occur during the night. A typical attack can cause steady pain in the right upper abdomen that increases rapidly and lasts from 30 minutes to several hours. There can be associated pain in the back between the shoulder blades or under the right shoulder.
Acute blockages of the bile ducts from gallstones necessitate urgent medical care. More acute symptoms include:
- Prolonged pain more than 5 hours
- Nausea and vomiting
- Fevers and/or chills
- Yellowish color of the skin or whites of the eyes (jaundice)
- clay-colored stools
Many people with gallstones have no symptoms; these gallstones are called “silent stones.” They do not interfere with gallbladder, liver, or pancreas function and do not need treatment.
How are gallstones diagnosed?
Gallstones are often discovered during tests for other health conditions. When gallstones are suspected to be the cause of symptoms there are different modalities that can be used.
- Ultrasound: typically the first test performed. This exam involves a handheld device, which a technician glides over the abdomen, sends sound waves toward the gallbladder. The sound waves bounce off the gallbladder, liver, and other organs, and their echoes make electrical impulses that create a picture of the gallbladder on a video monitor. If gallstones are present, the sound waves will bounce off them, too, showing their location.
- Computerized tomography (CT) scan: The CT scan is a noninvasive x ray that produces cross-section images of the body. The test may show the gallstones or complications, such as infection and rupture of the gallbladder or bile ducts.
- Cholescintigraphy (HIDA scan): The patient is injected with a small amount of nonharmful radioactive material that is absorbed by the gallbladder, which is then stimulated to contract. The test is used to diagnose abnormal contraction of the gallbladder or obstruction of the bile ducts.
- Endoscopic retrograde cholangiopancreatography (ERCP): ERCP is used to locate and remove stones in the bile ducts. Please refer to the section ERCP for more information.
- Blood tests: Aid in detecting signs of infection, obstruction, pancreatitis, or jaundice.
Because gallstone symptoms may be similar to those of a heart attack, appendicitis, ulcers, irritable bowel syndrome, hiatal hernia, pancreatitis, and hepatitis, an accurate diagnosis is important.
How are gallstones treated?
If the work up reveals that the patient’s symptoms are the most likely cause of the symptoms then the patient will likely require surgical removal of the gallbladder, called a cholecystectomy. Surgery to remove the gallbladder, a nonessential organ, is one of the most common surgeries performed on adults in the United States.
Most cholecystectomies are performed with laparoscopy. After the patient is sedated under general anesthesia, the surgeon makes several tiny incisions in the abdomen and inserts a laparoscope and a miniature video camera. The camera sends a magnified image from inside the body to a video monitor, giving the surgeon a close-up view of the organs and tissues. While watching the monitor, the surgeon uses the instruments to carefully separate the gallbladder from the liver, bile ducts, and other structures. Then the surgeon cuts the cystic duct and removes the gallbladder through one of the small incisions.
Recovery after laparoscopic surgery usually involves only one night in the hospital, and normal activity can be resumed after a few days at home. Because the abdominal muscles are not cut during laparoscopic surgery, patients have less pain and fewer complications than after “open” surgery, which requires a 5- to 8-inch incision across the abdomen. If tests show the gallbladder has severe inflammation, infection, or scarring from other operations, the surgeon may perform open surgery to remove the gallbladder. In some cases, open surgery is planned; however, sometimes these problems are discovered during the laparoscopy and the surgeon must make a larger incision. Recovery from open surgery usually requires 3 to 5 days in the hospital and several weeks at home. Open surgery is necessary in about 5 percent of gallbladder operations.
The most common complication in gallbladder surgery is injury to the bile ducts. An injured common bile duct can leak bile and cause a painful and potentially dangerous infection. Mild injuries can sometimes be treated nonsurgically. Major injury, however, is more serious and requires additional surgery.
If there is a suspicion that there are gallstones are present in the bile ducts, then Dr. Makhani may need to perform an ERCP to locate and remove them before gallbladder surgery. Occasionally, a person who has had a cholecystectomy is diagnosed with a gallstone in the bile ducts weeks, months, or even years after the surgery. The ERCP procedure is usually successful in removing the stone in these cases.
Nonsurgical approaches are used only in special situations, such as when a patient has a serious medical condition preventing surgery, and only for cholesterol stones. Stones commonly recur within 5 years in patients treated nonsurgically.
Do people need a gallbladder?
Fortunately, the gallbladder is an organ people can live without. The liver produces enough bile to digest a normal diet. Once the gallbladder is removed, bile flows out of the liver through the hepatic ducts into the common bile duct and directly into the small intestine, instead of being stored in the gallbladder. Because now the bile flows into the small intestine more often, softer and more frequent stools can occur in some people. These changes are usually temporary, but symptoms that persist may need further investigation and/or treatment.